| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376978 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.
Graphical abstractSynthesis and HCV NS3 serine protease inhibitory activity of P2–P4 macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Ashok Arasappan, F. George Njoroge, Kevin X. Chen, Srikanth Venkatraman, Tejal N. Parekh, Haining Gu, John Pichardo, Nancy Butkiewicz, Andrew Prongay, Vincent Madison, Viyyoor Girijavallabhan,