| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377010 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A novel series of 3,4-diaminocyclobut-3-ene-1,2-diones was prepared and found to show potent inhibitory activity of CXCR2 binding and IL-8-mediated chemotaxis of a CXCR2-expressing cell line. Microsome stability and Caco2 studies were subsequently used to show that compounds of this chemotype are predicted to have good oral bioavailability and are thus suitable for pharmaceutical development.
Graphical abstractA novel series of 3,4-diaminocyclobut-3-ene-1,2-diones was prepared with potent inhibitory activity of CXCR2 binding and IL-8-mediated chemotaxis.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
J. Robert Merritt, Laura L. Rokosz, Kingsley H. Nelson Jr., Bernd Kaiser, Wei Wang, Tara M. Stauffer, Lynne E. Ozgur, Adriane Schilling, Ge Li, John J. Baldwin, Arthur G. Taveras, Michael P. Dwyer, Jianping Chao,