| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377013 | Bioorganic & Medicinal Chemistry Letters | 2006 | 7 Pages |
Abstract
Three new perylene derivatives with branched ionizable side chains were synthesized, and their G-quadruplex binding specificities were compared by spectroscopic and electrophoretic analysis with two well-studied G-quadruplex ligands: PIPER and TmPyP4. The value of pH and consequent charge formation and self-aggregation of these perylene derivatives influences not only the type of G-quadruplex formation, but also the G-quadruplex binding selectivity.
Graphical abstractThree new perylene derivatives with branched ionizable side chains were investigated for their G-quadruplex binding specificities, in comparison with two well-studied G-quadruplex ligands: PIPER and TmPyP4.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wirote Tuntiwechapikul, Thanachai Taka, Mathilde Béthencourt, Luksana Makonkawkeyoon, T. Randall Lee,