| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377097 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
The antimalarial synthetic ozonide OZ277 (RBx11160) was hydroxylated by human liver microsomes at the distal bridgehead carbon atoms of the spiroadamantane substructure to form two carbinol metabolites devoid of antimalarial activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lin Zhou, André Alker, Armin Ruf, Xiaofang Wang, Francis C.K. Chiu, Julia Morizzi, Susan A. Charman, William N. Charman, Christian Scheurer, Sergio Wittlin, Yuxiang Dong, Daniel Hunziker, Jonathan L. Vennerstrom,