| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377098 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Two new cyclohexenones (antheminones A and B) and a new cyclohexanone, (antheminone C) along with five known compounds were isolated from the leaves of Anthemis maritima L. The structures were mainly deduced from extensive 1D and 2D NMR spectroscopy and mass spectrometry. The new compounds were tested in vitro for their cytotoxic activity against adherent and non-adherent cancer cell lines. Antheminones A and C exhibited significant antiproliferative activity against leukemia cells with IC50 values ranging from 3.2 to 14 μM.
Graphical abstractThree new compounds, antheminones A (1), B (2), and C (3) were isolated from the leaves of Anthemis maritima. These compounds exhibited significant antiproliferative activity against leukemia cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
