| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377101 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
High-throughput screening identified a low molecular weight antagonist of CXCR3 displaying micromolar activity in a membrane filtration-binding assay. Systematic modification of the benzimidazole core and tethered acetophenone moiety established tractable SAR of analogs with improved physicochemical properties and sub-micromolar activity across both human and murine receptors.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Martin E. Hayes, Grier A. Wallace, Pintipa Grongsaard, Agnieszka Bischoff, Dawn M. George, Wenyan Miao, Michael J. McPherson, Robert H. Stoffel, David W. Green, Gregory P. Roth,