| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377105 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
We describe the SAR, in terms of heterocyclic replacements, for a series of pyrazole EP1 receptor antagonists. This study led to the identification of several aromatic heterocyclic replacements for the pyrazole in the original compound. Investigation of replacements for the methylene linker uncovered disparate SAR in the thiazole and pyridine series.
Graphical abstractThe synthesis and biological activity of a series of novel methylene-linked heterocyclic EP1 receptor antagonists is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Adrian Hall, Rino A. Bit, Susan H. Brown, Anita Chowdhury, Gerard M.P. Giblin, David N. Hurst, Ian R. Kilford, Xiao Lewell, Alan Naylor, Tiziana Scoccitti,