| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377111 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Tricyclic 6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione was identified as a novel scaffold for Aurora kinase A inhibition through virtual screening. SAR exploration coupled with molecular modeling of 8a reveals the minimum pharmacophore requirements for Aurora kinase A inhibition.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold](/preview/png/1377111.png "First Page Preview: Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold")
Authors
Mohane Selvaraj Coumar, Jian-Sung Wu, Jiun-Shyang Leou, Uan-Kang Tan, Chung-Yu Chang, Teng-Yuan Chang, Wen-Hsing Lin, John T.-A. Hsu, Yu-Sheng Chao, Su-Ying Wu, Hsing-Pang Hsieh,