| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377115 | Bioorganic & Medicinal Chemistry Letters | 2008 | 7 Pages |
Abstract
The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC50 = 0.0008 μM) served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice.
Graphical abstractDiscovery of a series of novel 2,4-disubstituted arylamides as potential anti-inflammatory agents is described. Compound 8 was utilized in an in vivo CIA model to evaluate the therapeutic potential of FMS inhibition.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Carl R. Illig, Jinsheng Chen, Mark J. Wall, Kenneth J. Wilson, Shelley K. Ballentine, M. Jonathan Rudolph, Renee L. DesJarlais, Yanmin Chen, Carsten Schubert, Ioanna Petrounia, Carl S. Crysler, Christopher J. Molloy, Margery A. Chaikin, Carl L. Manthey,