Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377118 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A series of 8-aminomethylated derivatives (1a–1j) were prepared by Mannich reaction of oroxylin A (1) with appropriate primary or secondary amines and para-formaldehyde. All the compounds were tested for their α-glucosidase inhibition activity against both yeast and rat intestinal α-glucosidase. Some of the compounds demonstrated significantly better α-glucosidase inhibitory activity than the parent compound (oroxylin A).
Graphical abstractA series of 8-aminomethylated derivatives of oroxylin A were prepared by Mannich reaction and their α-glucosidase inhibition activities were studied.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
T. Hari Babu, V. Rama Subba Rao, Ashok K. Tiwari, K. Suresh Babu, P.V. Srinivas, Amtul Z. Ali, J. Madhusudana Rao,