Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377120 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
A series of tri- and tetra-substituted naphthalene diimides have been designed and synthesized. Several compounds show exceptional affinity for telomeric G-quadruplex DNA in classical and competition FRET assays and SPR studies. They inhibit telomerase in the TRAP assay, and show potent senescence-based short-term anti-proliferative effects on MCF7 and A549 cancer cell lines, and localize in the nucleus and particularly the nucleolus of MCF7 cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Francisco Cuenca, Olga Greciano, Mekala Gunaratnam, Shozeb Haider, Deeksha Munnur, Rupesh Nanjunda, W. David Wilson, Stephen Neidle,