| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377121 | Bioorganic & Medicinal Chemistry Letters | 2008 | 7 Pages |
Abstract
Tramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. O-Alkyl, N-desmethyl, and non-phenol containing derivatives of tramadol were synthesized to probe their effect on metabolic stability and both in vitro and in vivo potency.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Liming Shao, Michael Hewitt, Thomas P. Jerussi, Frank Wu, Scott Malcolm, Paul Grover, Kevin Fang, Patrick Koch, Chris Senanayake, Nandkumar Bhongle, Seth Ribe, Roger Bakale, Mark Currie,