| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377125 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
A series of imidazopyridines were evaluated as potential sodium channel blockers for the treatment of neuropathic pain. Several members were identified with good hNav1.7 potency and excellent rat pharmacokinetic profiles. Compound 4 had good efficacy (52% and 41% reversal of allodynia at 2 and 4 h post-dose, respectively) in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain when dosed orally at 10 mg/kg.
Graphical abstractA series of imidazopyridines were evaluated as hNav1.7 blockers.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Clare London, Scott B. Hoyt, William H. Parsons, Brande S. Williams, Vivien A. Warren, Richard Tschirret-Guth, McHardy M. Smith, Birgit T. Priest, Erin McGowan, William J. Martin, Kathryn A. Lyons, Xiaohua Li, Bindhu V. Karanam, Nina Jochnowitz,