Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377128 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear analogues. The results showed completely a different behaviour from similarly branched alcohols, supporting the key role of the ammonium-carbamate polar head in the enhancing activity of T.
Graphical abstractSeries of Transkarbam 12 derivatives with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear analogues.Figure optionsDownload full-size imageDownload as PowerPoint slide