Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids

4-Amino analogues prepared from β-boswellic acid and 11-keto-β-boswellic acid, wherein the carboxyl group in ursane nucleus was replaced by an amino function via Curtius reaction, displayed improved cytotoxicity than the parent molecules. The same molecules also exhibited apoptotic activity by inducing DNA fragmentation.

Graphical abstractSemi-synthetic 3-hydroxy-4-amino analogues prepared from boswellic acids, replacing carboxylic acid by an amino function, exhibited improved cytotoxicity as well as apoptotic activity.Figure optionsDownload full-size imageDownload as PowerPoint slide