Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377140 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Stereoselective synthesis of 1, one of biologically active naphthoquinones from a Brazilian traditional medicine Tabebuia avellanedae, was achieved by utilizing Noyori reduction as a key step. Compound 1 displayed potent cytotoxicity against several human tumor cell lines, whereas it showed lower cytotoxicity against some human normal cell lines compared with that of mitomycin. On the other hand, its enantiomer was less active toward the tumor cell lines than 1.
Graphical abstractThe stercoselective synthesis of naphthoquinone 1 and its biological evaluation are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mitsuaki Yamashita, Masafumi Kaneko, Akira Iida, Harukuni Tokuda, Katsumi Nishimura,