| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377151 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of benzimidazole compounds containing pendant alcohol and amine moieties was found to be active against checkpoint kinase Chk2. These compounds were prepared to examine a potential hydrogen bond interaction with an active site residue and to investigate replacement of a biaryl linker with an aliphatic system in an effort to improve solubility.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Danielle K. Neff, Alice Lee-Dutra, Jonathan M. Blevitt, Frank U. Axe, Michael D. Hack, Johnathan C. Buma, Raymond Rynberg, Anders Brunmark, Lars Karlsson, J. Guy Breitenbucher,