Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377158 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2, 5, 11, and 13 showed a high CB2 affinity and CB2 versus CB1 selectivity, in agreement with molecular modeling studies. Furthermore, compound 2 also exhibited in vivo antinociceptive effects.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Clementina Manera, Maria Grazia Cascio, Veronica Benetti, Marco Allarà, Tiziano Tuccinardi, Adriano Martinelli, Giuseppe Saccomanni, Elisa Vivoli, Carla Ghelardini, Vincenzo Di Marzo, Pier Luigi Ferrarini,