Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377162 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
We describe three novel regioisomeric series of aryl naphthyridine analogs, which are potent antagonists of the Class III GPCR mGlu5 receptor. The synthesis and in vitro and in vivo pharmacological activities of these analogs are discussed.
Graphical abstractWe describe three novel regioisomeric series of aryl naphthyridine analogs, which are potent antagonists of the Class III GPCR mGlu5 receptor. The synthesis and in vitro and in vivo pharmacological activities of these analogs are discussed.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Paul Galatsis, Koji Yamagata, John A. Wendt, Cleo J. Connolly, John W. Mickelson, Jared B.J. Milbank, Susan E. Bove, Christopher S. Knauer, Rachel M. Brooker, Corinne E. Augelli-Szafran, Roy D. Schwarz, Jack J. Kinsora, Kenneth S. Kilgore,