Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377170 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A hit generation and exploration approach led to the discovery of 31 (2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide), a potent, novel inhibitor of Aurora-A, Aurora-B and Aurora-C kinases with IC50 values of 0.042, 0.198 and 0.227 μM, respectively. Compound 31 inhibits cell proliferation and has good microsomal stability.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vassilios Bavetsias, Chongbo Sun, Nathalie Bouloc, Jóhannes Reynisson, Paul Workman, Spiros Linardopoulos, Edward McDonald,