Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377183 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Improved synthetic methods are reported for the preparation of sulfenamide derivatives of carbamazepine (CBZ) for evaluation as prodrugs. These sulfenamide prodrugs were designed to rapidly release CBZ in vivo by cleavage of the sulfenamide bond by chemical reaction with glutathione and other sulfhydryl compounds. Physicochemical characterization and in vivo conversion of a new prodrug of CBZ was evaluated to further establish the proof of concept of the sulfenamide prodrug approach.
Graphical abstractThe objective of this report is to introduce the novel application of sulfenamides as water-soluble prodrugs of the urea compound, carbamazaepine.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jeffrey N. Hemenway, Kwame Nti-Addae, Victor R. Guarino, Valentino J. Stella,