| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377190 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Several 1,8-naphthyridine-3-carboxamide derivatives (8–23) were synthesized and tested for in vitro cytotoxicity against eight cancer cell lines and a normal cell line. Compound 12 exhibited high cytotoxicity (IC50 = 1.37 μM) in HBL-100 (breast) cell line while compounds 17 (IC50 = 3.7 μM) and 22 (IC50 = 3.0 μM) have shown high cytotoxicity in KB (oral) and SW-620 (colon) cell lines, respectively. The synthesized 1,8-naphthyridine-3-carboxamides were also evaluated for anti-inflammatory and myeloprotective activities, indicated by modulation in cytokine and chemokine levels secreted by dendritic cells.
Graphical abstractCompounds 12 exhibited high cytotoxicity on HBL-100 (breast) cell line while compounds 17 and 22 have shown high cytotoxicity on KB (oral) and SW-620 (colon) cell lines, respectively.Figure optionsDownload full-size imageDownload as PowerPoint slide
