| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377198 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
An efficient and straightforward methodology for the parallel solid-phase synthesis of a variety of new macrocyclic oligoheterocycles is described. Exhaustive reduction of resin-bound cyclic polyamides using borane generates polyamines. Treatment of separated pairs of amines with a variety of bifunctional reagents provides, following cleavage from the solid support, the desired macrocyclic oligoheterocyclic (MOH) compounds in good yields and purities.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Adel Nefzi, Rodegar T. Santos,