| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377201 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of diaryl amides was designed and synthesized as novel nonethynyl mGluR5 antagonists. The systematic variation of the pharmacophoric groups led to the identification of a lead compound that demonstrated micromolar affinity for the mGluR5. Further optimization resulted in compounds with improved binding affinities and antagonist profiles, in vitro.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Santosh S. Kulkarni, Barbara Nightingale, Christina M. Dersch, Richard B. Rothman, Amy Hauck Newman,