| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377209 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A library consisting of 60 arylpiperazines modified with N-acylated amino acids was prepared on BAL linker SynPhase™ Lanterns and evaluated in vitro for 5-HT1A receptor affinity. Biological screening, followed by a simple Fujita–Ban analysis, enabled the description of structure–activity relationships and allowed the selection of some potent, high-affinity ligands for in vivo pharmacological investigations.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paweł Zajdel, Gilles Subra, Andrzej J. Bojarski, Beata Duszyńska, Maciej Pawłowski, Jean Martinez,