| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377211 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The synthesis and biological evaluation of novel tetrahydroisoquinoline, tetrahydroquinoline, and tetrahydroazepine antagonists of the human and rat H3 receptors are described. The substitution around these rings as well as the nature of the substituent on nitrogen is explored. Several compounds with high affinity and selectivity for the human and rat H3 receptors are reported.
Graphical abstractThe synthesis and biological evaluation of novel tetrahydroisoquinoline, tetrahydroquinoline, and tetrahydroazepine antagonists of the human and rat H3 receptors are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Cynthia D. Jesudason, Lisa S. Beavers, Jeffrey W. Cramer, Joelle Dill, Don R. Finley, Craig W. Lindsley, F. Craig Stevens, Robert A. Gadski, Samuel W. Oldham, R. Todd Pickard, Christopher S. Siedem, Dana K. Sindelar, Ajay Singh, Brian M. Watson,