| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377214 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The synthesis and preliminary structure–activity relationship of a series of pyrrolidinones are described. These pyrrolidinones have been characterized as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) which are highly potent against wild-type and drug-resistant human immunodeficiency viruses (HIV-1).
Graphical abstractN-Aryl pyrrolidinones as novel anti-HIV-1 agents is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Baogen Wu, Kelli Kuhen, Truc Ngoc Nguyen, David Ellis, Beth Anaclerio, Xiaohui He, Kunyong Yang, Donald Karanewsky, Hong Yin, Karen Wolff, Kimberly Bieza, Jeremy Caldwell, Yun He,