Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377215 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
Using a scaleable, directed library approach based on orthogonally protected advanced intermediates, we have prepared a series of potent keto-1,2,4-oxadiazoles designed to explore the P2 binding pocket of human mast cell tryptase, while building in a high degree of selectivity over human trypsin and other serine proteases.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
James T. Palmer, Robert M. Rydzewski, Rohan V. Mendonca, David Sperandio, Jeffrey R. Spencer, Bernard L. Hirschbein, Julia Lohman, Jeri Beltman, Margaret Nguyen, Liang Liu,