Article ID Journal Published Year Pages File Type
1377215 Bioorganic & Medicinal Chemistry Letters 2006 6 Pages PDF
Abstract

Using a scaleable, directed library approach based on orthogonally protected advanced intermediates, we have prepared a series of potent keto-1,2,4-oxadiazoles designed to explore the P2 binding pocket of human mast cell tryptase, while building in a high degree of selectivity over human trypsin and other serine proteases.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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