| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377216 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of four prodrugs directed against Trypanosoma brucei aldolase bearing various transient enzyme-labile phosphate protecting groups was developed. Herein, we describe the synthesis and evaluation of cell permeation of these prodrugs. The oxymethyl derivative was the most efficient prodrug with a good recovering of the free drug (IC50 = 20 μM) and without any measurable cytotoxicity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Laurent Azéma, Christian Lherbet, Cécile Baudoin, Casimir Blonski,