Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377221 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
The disruption of the p53-Hdm2 protein–protein interaction induces cell growth arrest and apoptosis. We have identified the 1,4-benzodiazepine-2,5-dione scaffold as a suitable template for inhibiting this interaction by binding to the Hdm2 protein. Several compounds have been made with improved potency, solubility, and cell-based activities.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kristi Leonard, Juan Jose Marugan, Pierre Raboisson, Raul Calvo, Joan M. Gushue, Holly K. Koblish, Jennifer Lattanze, Shuyuan Zhao, Maxwell D. Cummings, Mark R. Player, Anna C. Maroney, Tianbao Lu,