Article ID Journal Published Year Pages File Type
1377221 Bioorganic & Medicinal Chemistry Letters 2006 6 Pages PDF
Abstract

The disruption of the p53-Hdm2 protein–protein interaction induces cell growth arrest and apoptosis. We have identified the 1,4-benzodiazepine-2,5-dione scaffold as a suitable template for inhibiting this interaction by binding to the Hdm2 protein. Several compounds have been made with improved potency, solubility, and cell-based activities.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , , , , , , , , ,