| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377225 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts.
Graphical abstractA series of heteroaryl-substituted bis-trifluoromethyl carbinols 3 were prepared and evaluated as malonyl-CoA decarboxylase inhibitors. Several thiazole derivatives showed potent in vitro inhibitory activities and caused a 5-fold stimulation of glucose oxidation rates in isolated working rat hearts.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Jie-Fei Cheng, Chi Ching Mak, Yujin Huang, Richard Penuliar, Masahiro Nishimoto, Lin Zhang, Mi Chen, David Wallace, Thomas Arrhenius, Donald Chu, Guang Yang, Miguel Barbosa, Rick Barr, Jason R.B. Dyck, Gary D. Lopaschuk, Alex M. Nadzan,