Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377235 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
SAR and PK studies led to the identification of N-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-methanesulfonylphenyl] propyl}piperidin-4-yl)-N-ethyl-2-[4-methanesulfonylphenyl]acetamide as a highly potent and selective ligand for the human CCR5 chemokine receptor with good oral pharmacokinetic properties.
Graphical abstractSAR and PK studies led to the identification of compound 9g as a highly potent and selective ligand for the human CCR5 chemokine receptor with good oral pharmacokinetic properties.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
John G. Cumming, Simon J. Brown, Anne E. Cooper, Alan W. Faull, Anthony P. Flynn, Ken Grime, John Oldfield, John S. Shaw, Emma Shepherd, Howard Tucker, David Whittaker,