Article ID Journal Published Year Pages File Type
1377235 Bioorganic & Medicinal Chemistry Letters 2006 4 Pages PDF
Abstract

SAR and PK studies led to the identification of N-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-methanesulfonylphenyl] propyl}piperidin-4-yl)-N-ethyl-2-[4-methanesulfonylphenyl]acetamide as a highly potent and selective ligand for the human CCR5 chemokine receptor with good oral pharmacokinetic properties.

Graphical abstractSAR and PK studies led to the identification of compound 9g as a highly potent and selective ligand for the human CCR5 chemokine receptor with good oral pharmacokinetic properties.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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