| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377238 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Stereoselective reduction of dehydroalanine double bond in nocathiacin I afforded the primary amide 2. Enzymatic hydrolysis of the amide 2 provided the carboxylic acid 3, which upon coupling with a variety of amines furnished amides 4–32. Some of these semi-synthetic derivatives have retained very good antibacterial activity and have improved aqueous solubility.
Graphical abstractThe synthesis and antibacterial activity of nocathiacin I analogues is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
B. Narasimhulu Naidu, Margaret E. Sorenson, John D. Matiskella, Wenying Li, Justin B. Sausker, Yunhui Zhang, Timothy P. Connolly, Kin S. Lam, Joanne J. Bronson, Michael J. Pucci, Hyekyung Yang, Yasutsugu Ueda,