| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377243 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A novel series of 2-(1,2,4-oxadiazol-5-yl)-1H-indole derivatives as nociceptin/orphanin FQ (N/OFQ) receptor antagonists was discovered. Systematic modification of our original lead by changing the pendant functional groups, linker, heterocyclic core, and basic side chain revealed the structure–activity requirements for this novel template and resulted in the identification of more potent analog with improved potency as compared to the parent compound.
Graphical abstractA novel series of 2-(1,2,4-oxadiazol-5-yl)-1H-indole derivatives as nociceptin/orphanin FQ (N/OFQ) receptor antagonists was discovered.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuichi Sugimoto, Atsushi Shimizu, Tetsuya Kato, Atsushi Satoh, Satoshi Ozaki, Hisashi Ohta, Osamu Okamoto,