| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377247 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Quercetin is a kind of flavonoid which has been proved to exhibit anti-tumor activity. The interaction modes of quercetins with monomeric and dimeric G-quadruplexes were studied by absorption, fluorescence, CD, and 1H NMR spectroscopies. The ligands were found to be stacked with terminal tetrads of monomeric G-quadruplexes by intercalation and bound to dimeric G-quadruplexes by groove binding.
Graphical abstractThe different interaction modes of monomeric and dimeric G-quadruplexes with quercetin are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hongxia Sun, Yalin Tang, Junfeng Xiang, Guangzhi Xu, Yazhou Zhang, Hong Zhang, Lianghua Xu,