Article ID Journal Published Year Pages File Type
1377250 Bioorganic & Medicinal Chemistry Letters 2006 5 Pages PDF
Abstract

We have synthesized and tested a series of novel 3,4,5-tri- and 4,5-disubstituted oxazolidinones for their ability to bind two structurally related T box antiterminator model RNAs. We have found that optimal binding selectivity is found in a small group of 4,5-disubstituted oxazolidinones.

Graphical abstractSeveral oxazolidinone analogs were prepared and examined for binding to two structurally related T box antiterminator model RNAs, AM1A, and AM1A(C11U).Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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