Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377250 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
We have synthesized and tested a series of novel 3,4,5-tri- and 4,5-disubstituted oxazolidinones for their ability to bind two structurally related T box antiterminator model RNAs. We have found that optimal binding selectivity is found in a small group of 4,5-disubstituted oxazolidinones.
Graphical abstractSeveral oxazolidinone analogs were prepared and examined for binding to two structurally related T box antiterminator model RNAs, AM1A, and AM1A(C11U).Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John Means, Steven Katz, Abhijit Nayek, Rajaneesh Anupam, Jennifer V. Hines, Stephen C. Bergmeier,