| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377309 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
The design, synthesis and structure-activity relationships of a novel series of CRF-1 receptor antagonist, the 1-aryl-4-alkylaminoisoquinolines, is described. The effects of substitution on the aromatic ring, the amino group and the isoquinoline core on CRF-1 receptor binding were investigated.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Taeyoung Yoon, Stéphane De Lombaert, Robbin Brodbeck, Michael Gulianello, Jayaraman Chandrasekhar, Raymond F. Horvath, Ping Ge, Mark T. Kershaw, James E. Krause, John Kehne, Diane Hoffman, DarÃo Doller, Kevin J. Hodgetts,