| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377314 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
A series of 3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (2a–h) and 1-benzoyl-3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (3a–h) were synthesized by condensation of chalcones with hydrazine hydrate in solvent system ethanol and DMF. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activity, and were compared with standard drug. Among the compounds studied, compound 2e showed more potent anti-inflammatory and analgesic activity than the standard drug, along with minimum ulcerogenic index.
Graphical abstractA series of 3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (2a–h) and 1-benzoyl-3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (3a–h) were synthesized by condensation of chalcones with hydrazine hydrate in solvent system ethanol and DMF. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activity, and were compared with standard drug flurbiprofen.Figure optionsDownload full-size imageDownload as PowerPoint slide
