| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377318 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Optimization of pyrazinoindolone inhibitors of MAPKAP-K2 (MK2) provides a reasonable balance of cellular potency and physicochemical properties. Mechanistic studies support the inhibition of MK2 which is responsible for the sub-micromolar cellular efficacy.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
D.R. Goldberg, Y. Choi, D. Cogan, M. Corson, R. DeLeon, A. Gao, L. Gruenbaum, M.H. Hao, D. Joseph, M.A. Kashem, C. Miller, N. Moss, M.R. Netherton, C.P. Pargellis, J. Pelletier, R. Sellati, D. Skow, C. Torcellini, Y.-C. Tseng, J. Wang, R. Wasti,