| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377319 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
This report describes the first small-molecule antagonists that specifically target the ligand-binding pocket of PDZ domains of NHERF1 multi-functional adaptor protein. Comparison of the peptide sequence homology between the native ligand of NHERF1 PDZ domains and an indole-based non-peptide chemical scaffold allowed the design of a small-molecule antagonist of NHERF1 PDZ domains.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anand Mayasundari, Antonio M. Ferreira, Liwen He, Neeraj Mahindroo, Don Bashford, Naoaki Fujii,