| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377320 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
We designed and synthesized a series of indole-2-amide-based compounds that antagonize interaction between the Dishevelled (Dvl) PDZ domain and a peptide derived from the natural PDZ ligand Frizzled-7 (Fz7). These compounds inhibit Tcf-mediated transcription activated by exogenous Dvl via the biochemical antagonism. We confirmed tumor cell-selective activation of caspases by these compounds.
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Organic Chemistry
Authors
Neeraj Mahindroo, Chandanamali Punchihewa, Allison M. Bail, Naoaki Fujii,