Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377321 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Structural analogues of JS-K, an anti-cancer lead compound, were prepared and their in vitro anti-leukemic activity was determined. The rate of nitric oxide release from the corresponding diazeniumdiolate anions did not appear to affect the anti-leukemic activity of the prodrug forms. Two compounds with potent inhibitory activity and a potentially favorable toxicological profile were identified.
Graphical abstractSynthesis and anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound, are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Harinath Chakrapani, Michael M. Goodblatt, Vidya Udupi, Swati Malaviya, Paul J. Shami, Larry K. Keefer, Joseph E. Saavedra,