Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377322 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Synthesis of hybrids of 1-deoxynojirimycin (DNJ) and 5-aryl-1,2,3-triazole as potential bifunctional inhibitors of angiogenesis is described. The DNJ component inhibits the biosynthesis of cell surface oligosaccharides necessary for angiogenesis, whereas the aryl-1,2,3-triazole inhibits methionine aminopeptidase II, a target in angiogenesis therapy. One bifunctional compound was a more potent inhibitor of angiogenesis in vitro than DNJ alone or the 5-aryl-1,2,3-triazole alone.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ying Zhou, Yunxue Zhao, Kathy M. O’ Boyle, Paul V. Murphy,