| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377334 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Modification of the prime side of a lead di-amide series of BACE-1 inhibitors was investigated. Inhibitors with reduced peptidic character are presented and two different enzyme-binding modes are described. The compounds described lower amyloid production in a cell-based assay at sub-micromolar concentrations.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Brian Clarke, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Andrew Faller, Julie Hawkins, Ishrut Hussain, David MacPherson, Graham Maile, Rosalie Matico, Peter Milner, Julie Mosley, Alan Naylor, Alistair O'Brien, Sally Redshaw, David Riddell,