| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377343 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A series of urea analogues related to SA6817 and a GSK phosphonic acid with reported ACE inhibitory activity were prepared and tested for dual ACE and ECE activities. Although excellent ACE and NEP inhibition was achieved, only modest ECE inhibition was observed with one analogue.
Graphical abstractA series of urea analogues related to SA6817 and a GSK phosphonic acid with reported ACE inhibitory activity were prepared and tested for dual ACE and ECE activities. Although excellent ACE and NEP inhibition was achieved, only modest ECE inhibition was observed with one analogue.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Stephen Hanessian, Sébastien Guesné, Ludivine Riber, Julien Marin, Alain Benoist, Philippe Mennecier, Alain Rupin, Tony J. Verbeuren, Guillaume De Nanteuil,