Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377350 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
The stereoselective synthesis of aminooxy-containing proline analogues bearing Fmoc/Boc or Fmoc/Mtt protection that renders them suitable for incorporation into peptides using Fmoc protocols is reported. Acid-catalyzed unmasking at the completion of peptide synthesis yields free aminooxy-functionalities for oxime formation through reaction with libraries of aldehydes. This allows post solid-phase diversification strategies that may facilitate structure–activity relationship studies.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fa Liu, Andrew G. Stephen, Robert J. Fisher, Terrence R. Burke Jr.,