| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377356 | Bioorganic & Medicinal Chemistry Letters | 2008 | 7 Pages |
Abstract
Piperazinebenzylamine derivatives from trans-4-(4-chlorophenyl)tetrahydrothiophene-3-carboxylic acid 6 and its S-oxide 7 and sulfone 8, and the tetrahydrofuran 9 and its two regioisomers 11 and 13 were synthesized and studied for their binding affinities at the human melanocortin-4 receptor. These five-membered ring constrained compounds possessed similar or lower potency compared to the acyclic analogs.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Joe A. Tran, Caroline W. Chen, Fabio C. Tucci, Wanlong Jiang, Beth A. Fleck, Chen Chen,