| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377359 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
The introduction and the optimization of an α-amino substituent based on a series of α-hydroxy-β-N-biaryl ether sulfonamide hydroxamates is described. The modification leads to a new series of MMP-2/MMP-9 inhibitors with enhanced inhibitory activities and improved ADME properties. An efficacy study on reducing the ischemia-induced brain edema in the rat transient middle cerebral artery occlusion (tMCAo) model is also demonstrated.
Graphical abstractA new series of α-amino-β-N-biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shyh-Ming Yang, Robert H. Scannevin, Bingbing Wang, Sharon L. Burke, Zhihong Huang, Prabha Karnachi, Lawrence J. Wilson, Kenneth J. Rhodes, Bharat Lagu, William V. Murray,