Three-component, one-pot synthesis of novel 2,4-substituted 5-azolylthiopyrimidine library for screening against anti-influenza virus A

A novel one-pot synthesis of 2,4-substituted 5-azolylthiopyrimidines is achieved by sequential Michael-addition of 3-iodochromones with mercaptoazole (or mercaptotriazoles) and then condensation with a variety of amidines. Compound A1B6C1 exhibits a potent anti-influenza virus A activity with an IC50 value of 21.56 mg/mL and SI value of 9.

Graphical abstractA novel three-component, one-pot reaction synthesize, 2,4-substituted 5-azolylthiopyrimidines and Compound A1B6C1 exhibits a potent anti-influenza virus A activity (IC50 = 21.56 mg/mL).Figure optionsDownload full-size imageDownload as PowerPoint slide