| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377384 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Rational replacement of the alkyne linker of mGluR5 antagonist MPEP gave 7-arylquinolines. SAR optimization gave an orally active compound with high affinity for the MPEP binding site.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jared B.J. Milbank, Christopher S. Knauer, Corinne E. Augelli-Szafran, Annette T. Sakkab-Tan, Kristin K. Lin, Koji Yamagata, Jennifer K. Hoffman, Nian Zhuang, John Thomas, Paul Galatsis, John A. Wendt, John W. Mickelson, Roy D. Schwarz, Jack J. Kinsora,